模型信息
中文名称:MERS-CoV MERS-CoV- Hu/Jordan-N3/2012滴鼻感染BALB/c小鼠模型
英文名称:MERS-CoV MERS-CoV- Hu/Jordan-N3/2012 intranasally infection BALB/c mouse model
类型:MERS-CoV感染动物模型
分级:NA
用途:用于MERS-CoV感染研究。
研制单位:马里兰大学学院市分校@@http://www.umd.edu/
保存单位:马里兰大学学院市分校@@http://www.umd.edu/
研究背景
暂无介绍
制备方法
BALB/c mice, 8–10 weeks of age, were intramuscularly vaccinated with either PBS, 1 μg, 3μg or 10 μg MERS-CoV S nanoparticles with or without 5 μg of Matrix-M1™ adjuvant (Novavax AB, Uppsala, Sweden), which has been previously described. Mice were vaccinated at days 0 and 21.On day 30 post-initial vaccination, vaccinated mice were transduced with AdCMVhDPP4 as described previously. Mice were then intranasally inoculated with 2.5×103 pfu of MERS-CoV(Jordan).
评价验证
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生物安全性
暂无介绍
讨论与结论
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了解中析
实验室仪器
合作客户
